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| [2009] 9. Taejung Kwon, You-Jin Won, Jong Seok Lee, Hongil Ha |
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| Poster :
Date : 09-11-09 22:40
Hit : 1532
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Publication; issue : 2009 Year 33 Vol 1 iss 53 p
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  (561.1K), Down : 58, 2009-11-09 22:40:13 | |
An Autopsy Case of Alzheimer's Disease
Kor J Legal Med 2009 May;33(1):53-6.
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Division of Forensic Medicine, National Institute of Scientific Investigation, Seoul, Korea. tjkwon@nisi.go.kr
Alzheimer's disease is the leading cause of dementia. We experienced a case of Alzheimer's disease who is 83-year-old woman killed by stab with a knife. She had been suffered from dementia for several years. At autopsy, the brain disclosed cortical atrophy in the frontal, temporal and parietal lobes, and hippocampus. Microscopically, many senile plaques and a few neurofibrillary tangles were observed at the cerebral cortex and hippocampus. Senile plaques were characterized by a spherical structure with or without a dense central core of amyloid, associated with dystrophic neurites. Neurofibrillary tangle was an intracellular filamentous lesion in the cell body of neuron. To our knowledge, this is a rare autopsy case in Korea, therefore, we report here-in and review the clinicopathologic features of Alzheimer's disease.
Key words : Alzheimer’s disease, dementia, pathology
Case report
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