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| [2007] 10. Seung-Ah Lee, Hyun-Ee Yim, Young-Yul You, Jang-Hee Kim |
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Date : 09-11-09 21:40
Hit : 1671
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Publication; issue : 2007 Year 31 Vol 2 iss 188 p
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  (1.9M), Down : 55, 2009-11-09 21:40:57 | |
Fatal Infectious Mononucleosis - A case report -
Kor J Legal Med 2007 Nov;31(2):188-91.
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Department of Pathology, Ajou University School of Medicine, Suwon, Korea. mrkjhk@yahoo.co.kr
Infectious mononucleosis(IM) is a benign self-limiting disease and result from a polyclonal B cell proliferation secondary to Epstein-Barr virus (EBV) infections. The infection is controlled by cytotoxic T cells triggered by EBV infected B cells. However, rare cases develop severe or fatal IM accompanied by hemophagocytic syndrome. We report a case of a 4-year-old girl who presented with high fever, hepatosplenomegaly, hepatic failure, pancytopenia and coagulopathy. Despite intensive treatment, the patient's condition deteriorated rapidly and died 3 days after admission. At autopsy, there was prominent infiltration of atypical lymphocytes with hemophagocytosis in multiple organs, especially liver, spleen and lymph nodes. Atypical lymphocytes were immunopositive for T cell markers and showed positive signal in EBV in situ hybridization.
Key words : EBV, Infectious mononucleosis, autopsy, hemophagocytic syndrome
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