Analysis of the Significance in the Forensic Application of the STR CSF1PO, STR TPOX, STR TH01 Loci.

Korean J Leg Med. 1998 May;22(1):40-49. Korean.

Department of Forensic Medicine, Chonnam University Medicine School, Korea.

Alleles and genotype frequencies and its distribution pattern for three STR loci; CSF1PO, TPOX, and TH01 were analyzed for the evaluation of the useful-ness of STR loci in the individual identification. STR CSF1PO locus showed 7 allele types and 18 genotypes. However, 3 of 7 allele types are related to 84.3% of population and 4 of 18 genotypes are related to 67.6% of population. Heterozygosity is 70.6%. STR TPOX locus showed 5 allele types and 12 genotypes. However, 2 of 5 llele types are related to 81.92% of population and 3 of 12 genotypes are related to 78.4% of population. Heterozygosity is 65.7%. STR TP01 locus showed 5 allele types and 13 genotypes. However, 2 of 5 llele types are related to 78.9% of population and 3 of 13 genotypes are re-lated to 71.6% of population. Heterozygosity is 68.6%. From the above results, CSF1PO, TPOX, and TH01 loci have small numbers of allele types and genotypes. Many population is included into the specific allele types and genotypes. So, statistical analysis of allele and genotype frequency may have risks of misinterpretation of negative results to positive results. To remove the statistical errors, more than three STR loci have to be used in individual identification and the distribution pattern of the frequency of allele types and genotypes have to be analyzed in the STR loci.